An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530)

The phenotypic transformation of well-differentiated epithelial carcinoma into a mesenchymal-like state provides cancer cells with the ability to disseminate locally and to metastasise. Different degrees of epithelial–mesenchymal transition (EMT) have been found to occur in carcinomas from breast, c...

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Detalhes bibliográficos
Main Authors: Huang, R Y-J, Wong, M K, Tan, T Z, Kuay, K T, Ng, A H C, Chung, V Y, Chu, Y-S, Matsumura, N, Lai, H-C, Lee, Y F, Sim, W-J, Chai, C, Pietschmann, E, Mori, S, Low, J J H, Choolani, M, Thiery, J P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847320/
https://ncbi.nlm.nih.gov/pubmed/24201814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.442
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