Slow accumulation of mutations in Xpc(−/−) mice upon induction of oxidative stress

XPC is one of the key DNA damage recognition proteins in the global genome repair route of the nucleotide excision repair (NER) pathway. Previously, we demonstrated that NER-deficient mouse models Xpa(−/−) and Xpc(−/−) exhibit a divergent spontaneous tumor spectrum and proposed that XPC might be fun...

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Main Authors: Melis, Joost P.M., Kuiper, Raoul V., Zwart, Edwin, Robinson, Joke, Pennings, Jeroen L.A., van Oostrom, Conny T.M., Luijten, Mirjam, van Steeg, Harry
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847164/
https://ncbi.nlm.nih.gov/pubmed/24084170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.08.019
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