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FamClash: A method for ranking the activity of engineered enzymes

This article introduces the computational procedure FamClash for analyzing incompatibilities in engineered protein hybrids by using protein family sequence data. All pairs of residue positions in the sequence alignment that conserve the property triplet of charge, volume, and hydrophobicity are firs...

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Hlavní autoři: Saraf, Manish C., Horswill, Alexander R., Benkovic, Stephen J., Maranas, Costas D.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC384708/
https://ncbi.nlm.nih.gov/pubmed/14981242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400065101
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