Sex differences in the prognostic significance of KRAS codons 12 and 13, and BRAF mutations in colorectal cancer: a cohort study

BACKGROUND: Activating KRAS and BRAF mutations predict unresponsiveness to EGFR-targeting therapies in colorectal cancer (CRC), but their prognostic value needs further validation. In this study, we investigated the impact of KRAS codons 12 and 13, and BRAF mutations on survival from CRC, overall an...

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Bibliografske podrobnosti
Main Authors: Wangefjord, Sakarias, Sundström, Magnus, Zendehrokh, Nooreldin, Lindquist, Kajsa Ericson, Nodin, Björn, Jirström, Karin, Eberhard, Jakob
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846575/
https://ncbi.nlm.nih.gov/pubmed/24020794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2042-6410-4-17
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