Retro-Inverso Carbohydrate Mimetic Peptides with Annexin1-Binding Selectivity, Are Stable In Vivo, and Target Tumor Vasculature

Previous research suggests that carbohydrate mimetic peptide IF7 (IFLLWQR) has an excellent targeting property to annexin1 (Anxa1), a specific marker on the tumor endothelium. However, IF7 is susceptible to proteolysis and has a poor stability in vivo. We prepared a D-amino acid, reverse sequence pe...

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Bibliographic Details
Main Authors: Chen, Xinyi, Fan, Zhuoyang, Chen, Yanzuo, Fang, Xiaoling, Sha, Xianyi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846562/
https://ncbi.nlm.nih.gov/pubmed/24312470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080390
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