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The calcitonin gene-related peptide receptor antagonist MK-8825 decreases spinal trigeminal activity during nitroglycerin infusion

BACKGROUND: Calcitonin gene-related peptide (CGRP) and nitric oxide (NO) are regarded as key mediators in migraine and other primary headaches. Migraineurs respond to infusion of nitroglycerin with delayed headaches, and inhibition of CGRP receptors has been shown to be effective in migraine therapy...

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Detalhes bibliográficos
Main Authors: Feistel, Stephan, Albrecht, Stephanie, Messlinger, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845525/
https://ncbi.nlm.nih.gov/pubmed/24256609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1129-2377-14-93
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