Evidence for the Involvement of Lfc and Tctex-1 in Axon Formation

RhoA and Rac play key and opposite roles during neuronal polarization. We now show that Lfc, a guanosine nucleotide exchange factor (GEF), localizes to the Golgi apparatus and growth cones of developing neurons and negatively regulates neurite sprouting and axon formation through a Rho signaling pat...

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Hlavní autoři: Conde, Cecilia, Arias, Cristina, Robin, Maria, Li, Aiqun, Saito, Masaki, Chuang, Jen-Zen, Nairn, Angus C., Sung, Ching-Hwa, Cáceres, Alfredo
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845415/
https://ncbi.nlm.nih.gov/pubmed/20463241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5420-09.2010
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