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Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins

Wnt proteins contain an unusual lipid modification, palmitoleic acid. Production of an active Wnt signal requires the acyltransferase Porcupine and depends on attachment of palmitoleic acid to Wnt. The source of this monounsaturated fatty acid has not been identified, and it is not known how Porcupi...

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Autors principals: Rios-Esteves, Jessica, Resh, Marilyn D.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845236/
https://ncbi.nlm.nih.gov/pubmed/24055053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.08.027
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