IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

Replication of lentiviruses generates different DNA forms, including RNA:DNA hybrids, ssDNA, and dsDNA. Nucleic acids stimulate innate immune responses, and pattern recognition receptors detecting dsDNA have been identified. However, sensors for ssDNA have not been reported, and the ability of RNA:D...

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Hlavní autoři: Jakobsen, Martin R., Bak, Rasmus O., Andersen, Annika, Berg, Randi K., Jensen, Søren B., Jin, Tengchuan, Laustsen, Anders, Hansen, Kathrine, Østergaard, Lars, Fitzgerald, Katherine A., Xiao, T. Sam, Mikkelsen, Jacob G., Mogensen, Trine H., Paludan, Søren R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845190/
https://ncbi.nlm.nih.gov/pubmed/24154727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311669110
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