Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition

Targeted therapeutics that block signal transduction through the RAS–RAF–MEK and PI3K–AKT–mTOR pathways offer significant promise for the treatment of human malignancies. Dual inhibition of MAP/ERK kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) with the potent and selective small-molecule inh...

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Main Authors: Kirkpatrick, Donald S., Bustos, Daisy J., Dogan, Taner, Chan, Jocelyn, Phu, Lilian, Young, Amy, Friedman, Lori S., Belvin, Marcia, Song, Qinghua, Bakalarski, Corey E., Hoeflich, Klaus P.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845176/
https://ncbi.nlm.nih.gov/pubmed/24218548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309473110
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