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Antibody biomarker discovery through in vitro directed evolution of consensus recognition epitopes

To enable discovery of serum antibodies indicative of disease and simultaneously develop reagents suitable for diagnosis, in vitro directed evolution was applied to identify consensus peptides recognized by patients’ serum antibodies. Bacterial cell-displayed peptide libraries were quantitatively sc...

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Detalhes bibliográficos
Main Authors: Ballew, John T., Murray, Joseph A., Collin, Pekka, Mäki, Markku, Kagnoff, Martin F., Kaukinen, Katri, Daugherty, Patrick S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845167/
https://ncbi.nlm.nih.gov/pubmed/24222690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314792110
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