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Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2
Allelic exclusion requires that the two alleles at antigen-receptor loci attempt to recombine variable (V), diversity (D), and joining (J) gene segments [V(D)J recombination] asynchronously in nuclei of developing lymphocytes. It previously was shown that T-cell receptor β (Tcrb) alleles frequently...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3845165/ https://ncbi.nlm.nih.gov/pubmed/24218622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310846110 |
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