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Site-2 protease substrate specificity and coupling in trans by a PDZ-substrate adapter protein

Site-2 proteases (S2Ps) are intramembrane metalloproteases that cleave transmembrane substrates in all domains of life. Many S2Ps, including human S2P and Mycobacterium tuberculosis Rip1, have multiple substrates in vivo, which are often transcriptional regulators. However, S2Ps will also cleave tra...

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Detalhes bibliográficos
Main Authors: Schneider, Jessica S., Reddy, Shilpa P., E, Hock Y., Evans, Henry W., Glickman, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845159/
https://ncbi.nlm.nih.gov/pubmed/24218594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305934110
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