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Site-2 protease substrate specificity and coupling in trans by a PDZ-substrate adapter protein
Site-2 proteases (S2Ps) are intramembrane metalloproteases that cleave transmembrane substrates in all domains of life. Many S2Ps, including human S2P and Mycobacterium tuberculosis Rip1, have multiple substrates in vivo, which are often transcriptional regulators. However, S2Ps will also cleave tra...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3845159/ https://ncbi.nlm.nih.gov/pubmed/24218594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305934110 |
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