Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH

Using a systematic, whole-genome analysis of enhancer activity of human-specific endogenous retroviral inserts (hsERVs), we identified an element, hsERV(PRODH), that acts as a tissue-specific enhancer for the PRODH gene, which is required for proper CNS functioning. PRODH is one of the candidate gen...

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Bibliographic Details
Main Authors: Suntsova, Maria, Gogvadze, Elena V., Salozhin, Sergey, Gaifullin, Nurshat, Eroshkin, Fedor, Dmitriev, Sergey E., Martynova, Natalia, Kulikov, Kirill, Malakhova, Galina, Tukhbatova, Gulnur, Bolshakov, Alexey P., Ghilarov, Dmitry, Garazha, Andrew, Aliper, Alexander, Cantor, Charles R., Solokhin, Yuri, Roumiantsev, Sergey, Balaban, Pavel, Zhavoronkov, Alex, Buzdin, Anton
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845128/
https://ncbi.nlm.nih.gov/pubmed/24218577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318172110
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