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Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation

Liver kinase b1 (Lkb1) protein kinase activity regulates cell growth and cell polarity. Here, we show Lkb1 is essential for maintaining a balance between mitotic and postmitotic cell fates in development of the mammalian skeleton. In this process, Lkb1 activity controls the progression of mitotic ch...

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Detalhes bibliográficos
Main Authors: Lai, Lick Pui, Lilley, Brendan N., Sanes, Joshua R., McMahon, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845115/
https://ncbi.nlm.nih.gov/pubmed/24218567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309001110
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