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Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes
One hypothesis to account for MHC-restriction by T cell receptors (TCRs) holds that there are several evolutionary-conserved residues in TCR variable regions that contact MHC. While this ‘germline-codon’ hypothesis is supported by various lines of evidence, it has been difficult to test. The difficu...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3844621/ https://ncbi.nlm.nih.gov/pubmed/23954306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.08.007 |
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