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The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase.

(+)-Hydantocidin, a recently discovered natural spironucleoside with potent herbicidal activity, is shown to be a proherbicide that, after phosphorylation at the 5' position, inhibits adenylosuccinate synthetase, an enzyme involved in de novo purine synthesis. The mode of binding of hydantocidi...

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Detalhes bibliográficos
Main Authors: Fonné-Pfister, R, Chemla, P, Ward, E, Girardet, M, Kreuz, K E, Honzatko, R B, Fromm, H J, Schär, H P, Grütter, M G, Cowan-Jacob, S W
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC38445/
https://ncbi.nlm.nih.gov/pubmed/8790347
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