The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase.

(+)-Hydantocidin, a recently discovered natural spironucleoside with potent herbicidal activity, is shown to be a proherbicide that, after phosphorylation at the 5' position, inhibits adenylosuccinate synthetase, an enzyme involved in de novo purine synthesis. The mode of binding of hydantocidin 5'-...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Fonné-Pfister, R, Chemla, P, Ward, E, Girardet, M, Kreuz, K E, Honzatko, R B, Fromm, H J, Schär, H P, Grütter, M G, Cowan-Jacob, S W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38445/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8790347/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.18.9431
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