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Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions
Holliday junctions (HJs), the DNA intermediates of homologous recombination need to be faithfully processed in order to preserve genome integrity. In human cells the BLM helicase complex promotes non-nucleolytic dissolution of double HJs. In vitro, HJs may be nucleolytically processed by MUS81-EME1,...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3844290/ https://ncbi.nlm.nih.gov/pubmed/24080495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.08.041 |
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