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Activation of Aicda gene transcription by Pax5 in plasmacytoma cells

Activation Induced Deaminase (AID) is an enzyme responsible for somatic hypermutation (SHM) and immunoglobulin heavy chain class switch recombination (CSR). Because AID causes double-stranded breaks in DNA, its expression is highly regulated and is normally restricted to germinal center B cells. Dys...

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Библиографические подробности
Главные авторы: Dege, Carissa, Hagman, James
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844280/
https://ncbi.nlm.nih.gov/pubmed/22956488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12026-012-8357-8
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