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Presenilins regulate the cellular activity of ryanodine receptors differentially through isotype-specific N-terminal cysteines
Presenilins (PS), endoplasmic reticulum (ER) transmembrane proteins, form the catalytic core of γ-secretase, an amyloid precursor protein processing enzyme. Mutations in PS lead to Alzheimer's disease (AD) by altering γ-secretase activity to generate pathologic amyloid beta and amyloid plaques...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3843983/ https://ncbi.nlm.nih.gov/pubmed/24029002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2013.09.001 |
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