Presenilins regulate the cellular activity of ryanodine receptors differentially through isotype-specific N-terminal cysteines

Presenilins (PS), endoplasmic reticulum (ER) transmembrane proteins, form the catalytic core of γ-secretase, an amyloid precursor protein processing enzyme. Mutations in PS lead to Alzheimer's disease (AD) by altering γ-secretase activity to generate pathologic amyloid beta and amyloid plaques...

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Main Authors: Payne, Andrew J., Gerdes, Bryan C., Naumchuk, Yuliya, McCalley, Audrey E., Kaja, Simon, Koulen, Peter
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843983/
https://ncbi.nlm.nih.gov/pubmed/24029002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2013.09.001
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