GPR35 Activation Reduces Ca(2+) Transients and Contributes to the Kynurenic Acid-Dependent Reduction of Synaptic Activity at CA3-CA1 Synapses

Limited information is available on the brain expression and role of GPR35, a Gi/o coupled receptor activated by kynurenic acid (KYNA). In mouse cultured astrocytes, we detected GPR35 transcript using RT-PCR and we found that KYNA (0.1 to 100 µM) decreased forskolin (FRSK)-induced cAMP production (p...

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Detalhes bibliográficos
Principais autores: Berlinguer-Palmini, Rolando, Masi, Alessio, Narducci, Roberto, Cavone, Leonardo, Maratea, Dario, Cozzi, Andrea, Sili, Maria, Moroni, Flavio, Mannaioni, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843712/
https://ncbi.nlm.nih.gov/pubmed/24312407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082180
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