MPP(+)-dependent inhibition of I(h) reduces spontaneous activity and enhances EPSP summation in nigral dopamine neurons

BACKGROUND AND PURPOSE: 1-Methyl-4-phenylpyridinium (MPP(+)), a potent parkinsonizing agent in primates and rodents, is a blocker of mitochondrial complex I, therefore MPP(+)-induced parkinsonism is believed to depend largely on mitochondrial impairment. However, it has recently been proposed that o...

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Hauptverfasser: Masi, A, Narducci, R, Landucci, E, Moroni, F, Mannaioni, G
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2013
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632244/
https://ncbi.nlm.nih.gov/pubmed/23323755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12104
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