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MPP(+)-dependent inhibition of I(h) reduces spontaneous activity and enhances EPSP summation in nigral dopamine neurons
BACKGROUND AND PURPOSE: 1-Methyl-4-phenylpyridinium (MPP(+)), a potent parkinsonizing agent in primates and rodents, is a blocker of mitochondrial complex I, therefore MPP(+)-induced parkinsonism is believed to depend largely on mitochondrial impairment. However, it has recently been proposed that o...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Blackwell Publishing Ltd
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3632244/ https://ncbi.nlm.nih.gov/pubmed/23323755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12104 |
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