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The 2 Å crystal structure of leucyl-tRNA synthetase and its complex with a leucyl-adenylate analogue

Leucyl-, isoleucyl- and valyl-tRNA synthetases are closely related large monomeric class I synthetases. Each contains a homologous insertion domain of ∼200 residues, which is thought to permit them to hydrolyse (‘edit’) cognate tRNA that has been mischarged with a chemically similar but non-cognate...

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Autors principals: Cusack, Stephen, Yaremchuk, Anna, Tukalo, Michael
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC384370/
https://ncbi.nlm.nih.gov/pubmed/10811626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.10.2351
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