Targeted gene silencing using a follicle-stimulating hormone peptide-conjugated nanoparticle system improves its specificity and efficacy in ovarian clear cell carcinoma in vitro

BACKGROUND: RNA interference technology has shown high therapeutic potential for cancer treatment. However, serum instability, poor tissue permeability and non-specific uptake of short interfering RNA (siRNA) limit its administration in vivo. To overcome these limitations and improve the specificity...

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Detalhes bibliográficos
Main Authors: Hong, Shanshan, Zhang, Xiaoyan, Chen, Jun, Zhou, Jiabing, Zheng, Yufang, Xu, Congjian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843555/
https://ncbi.nlm.nih.gov/pubmed/24252539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1757-2215-6-80
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