JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia

The principal morbidity and mortality in patients with essential thrombocythemia (ET) and polycythemia rubra vera (PV) stems from thrombotic events. Most patients with ET/PV harbor a JAK2V617F mutation, but its role in the thrombotic diathesis remains obscure. Platelet function studies in patients a...

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Hlavní autoři: Hobbs, Catherine M., Manning, Harriet, Bennett, Cavan, Vasquez, Louella, Severin, Sonia, Brain, Lauren, Mazharian, Alexandra, Guerrero, Jose A., Li, Juan, Soranzo, Nicole, Green, Anthony R., Watson, Steve P., Ghevaert, Cedric
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Platelets and Thrombopoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843237/
https://ncbi.nlm.nih.gov/pubmed/24085768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-06-501452
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