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Mutations in the Polybasic Juxtamembrane Sequence of Both Plasma Membrane- and Endoplasmic Reticulum-localized Epidermal Growth Factor Receptors Confer Ligand-independent Cell Transformation

Deregulation of ErbB receptor-tyrosine kinases is a hallmark of many human cancers. Conserved in the ErbB family is a cluster of basic amino acid residues in the cytoplasmic juxtamembrane region. We found that charge-silencing mutagenesis within this juxtamembrane region of the epidermal growth fact...

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Autori principali: Bryant, Kirsten L., Antonyak, Marc A., Cerione, Richard A., Baird, Barbara, Holowka, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843104/
https://ncbi.nlm.nih.gov/pubmed/24142702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.513333
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