The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans

Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA), playing a key role in diverse physiological and pathological processes. ATX exists in distinct splice variants, but isoform-specific functions remain elusive. Here we characterize the ATX...

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Autors principals: Houben, Anna J. S., van Wijk, Xander M. R., van Meeteren, Laurens A., van Zeijl, Leonie, van de Westerlo, Els M. A., Hausmann, Jens, Fish, Alexander, Perrakis, Anastassis, van Kuppevelt, Toin H., Moolenaar, Wouter H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537048/
https://ncbi.nlm.nih.gov/pubmed/23150666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.358416
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