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Full Implementation of the Genetic Code by Tryptophanyl-tRNA Synthetase Requires Intermodular Coupling

Tryptophanyl-tRNA Synthetase (TrpRS) Urzyme (fragments A and C), a 130-residue construct containing only secondary structures positioning the HIGH and KMSKS active site signatures and the specificity helix, accelerates tRNA(Trp) aminoacylation with ∼10-fold specificity toward tryptophan, relative to...

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Bibliografski detalji
Glavni autori: Li, Li, Carter, Charles W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843085/
https://ncbi.nlm.nih.gov/pubmed/24142809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510958
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