Trace element associated reduction of norleucine and norvaline accumulation during oxygen limitation in a recombinant Escherichia coli fermentation

BACKGROUND: Norleucine and norvaline belong to a group of non-canonical amino acids which are synthesized as byproducts in the branched chain amino acid metabolism of Escherichia coli. The earlier observed misincorporation of these rare amino acids into recombinant proteins has attracted increasing...

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Hlavní autoři: Biermann, Michael, Linnemann, Julia, Knüpfer, Uwe, Vollstädt, Sebastian, Bardl, Bettina, Seidel, Guido, Horn, Uwe
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842802/
https://ncbi.nlm.nih.gov/pubmed/24261588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-12-116
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