A Structured-based Model for the Decreased Activity of Ala222Val and Glu429Ala Methylenetetrahydrofolate Reductase (MTHFR) Mutants

The structure of human Methylenetetrahydrofolate Reductase (MTHFR) is not known either by NMR or by X-ray methods. Phosphorylation seems to play an important role in the functioning of this flavoprotein. MTHFR catalyzes an irreversible reaction in homocysteine metabolism. Phosphorylation decreases t...

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Hlavní autoři: Shahzad, Khuram, Hai, Abdul, Ahmed, Asifa, Kizilbash, Nadeem, Alruwaili, Jamal
Médium: Artigo
Jazyk:Inglês
Vydáno: Biomedical Informatics 2013
Témata:
Hypothesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842580/
https://ncbi.nlm.nih.gov/pubmed/24307772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6026/97320630009929
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