Reliable set-up for in-loop (11)C-carboxylations using Grignard reactions for the preparation of [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO()

Aim of this work was the implementation of a generalized in-loop synthesis for (11)C-carboxylations and subsequent (11)C-acylations on the TRACERlab FxC Pro platform. The set-up was tested using [carbonyl-(11)C]WAY-100635 and, for the first time, [(11)C]-(+)-PHNO. Its general applicability could be...

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Main Authors: Rami-Mark, Christina, Ungersboeck, Johanna, Haeusler, Daniela, Nics, Lukas, Philippe, Cecile, Mitterhauser, Markus, Willeit, Matthaeus, Lanzenberger, Rupert, Karanikas, Georgios, Wadsak, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Pergamon Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842501/
https://ncbi.nlm.nih.gov/pubmed/23974301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apradiso.2013.07.023
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