Cell-Produced α-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

α-Synuclein is central in Parkinson's disease pathogenesis. Although initially α-synuclein was considered a purely intracellular protein, recent data suggest that it can be detected in the plasma and CSF of humans and in the culture media of neuronal cells. To address a role of secreted α-synuc...

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Autori principali: Emmanouilidou, Evangelia, Melachroinou, Katerina, Roumeliotis, Theodoros, Garbis, Spiros D., Ntzouni, Maria, Margaritis, Lukas H., Stefanis, Leonidas, Vekrellis, Kostas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842464/
https://ncbi.nlm.nih.gov/pubmed/20484626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5699-09.2010
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