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Defective acidification of endosomes in Chinese hamster ovary cell mutants "cross-resistant" to toxins and viruses.
Like many physiological ligands, several viruses and toxins enter mammalian cells through receptor-mediated endocytosis. Once internalized, the nucleic acids of several viruses and the toxic subunit of diphtheria toxin gain access to the cytosol of the host cell through an acidic intracellular compa...
Enregistré dans:
| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1983
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384246/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6577430/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.17.5315 |
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