In the Absence of Effector Proteins, the Pseudomonas aeruginosa Type Three Secretion System Needle Tip Complex Contributes to Lung Injury and Systemic Inflammatory Responses

Herein we describe a pathogenic role for the Pseudomonas aeruginosa type three secretion system (T3SS) needle tip complex protein, PcrV, in causing lung endothelial injury. We first established a model in which P. aeruginosa wild type strain PA103 caused pneumonia-induced sepsis and distal organ dys...

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Detalhes bibliográficos
Main Authors: Audia, Jonathon P., Lindsey, Ashley S., Housley, Nicole A., Ochoa, Courtney R., Zhou, Chun, Toba, Michie, Oka, Masahiko, Annamdevula, Naga S., Fitzgerald, Meshann S., Frank, Dara W., Alvarez, Diego F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842252/
https://ncbi.nlm.nih.gov/pubmed/24312357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081792
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