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PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway

Insulin stimulated translocation of the glucose transporter GLUT4 from the cytosol to the plasma membrane in a concentration (1 nM–1 μM)-dependent manner and increased glucose uptake in 3T3-L1 adipocytes. Insulin-induced GLUT4 translocation to the cell surface was prevented by the phosphoinositide 3...

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Hlavní autoři: Tsuchiya, A, Kanno, T, Nishizaki, T
Médium: Artigo
Jazyk:Inglês
Vydáno: Bioscientifica Ltd 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842210/
https://ncbi.nlm.nih.gov/pubmed/24169049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-13-0172
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