Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice

OBJECTIVE: Inflammatory bowel diseases (IBD) have been intrinsically linked to a deregulated cytokine network, but novel therapeutic principles are urgently needed. Here we identify the interleukin (IL)-33 and its receptor ST2 as key negative regulators of wound healing and permeability in the colon...

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Main Authors: Sedhom, Mamdouh A K, Pichery, Mélanie, Murdoch, Jenna R, Foligné, Benoit, Ortega, Nathalie, Normand, Sylvain, Mertz, Kirsten, Sanmugalingam, Devika, Brault, Lea, Grandjean, Teddy, Lefrancais, Emma, Fallon, Padraic G, Quesniaux, Valérie, Peyrin-Biroulet, Laurent, Cathomas, Gieri, Junt, Tobias, Chamaillard, Mathias, Girard, Jean-Philippe, Ryffel, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2013
Assuntos:
Experimental Colitis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841767/
https://ncbi.nlm.nih.gov/pubmed/23172891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-301785
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