Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.

Increased production of fetal hemoglobin (HbF) was observed in a patient with sickle cell anemia treated with 5-azacytidine. Each of four courses of therapy resulted in a rapid and prolonged increase in the percentage of HbF containing reticulocytes (F reticulocytes) and HbF containing erythrocytes...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Charache, S, Dover, G, Smith, K, Talbot, C C, Moyer, M, Boyer, S
Format: Artigo
Langue:Inglês
Publié: 1983
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC384141/
https://ncbi.nlm.nih.gov/pubmed/6192443
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires