Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia.

Hydroxyurea has proven efficacy in children and adults with sickle cell anemia (SCA), but with considerable inter-individual variability in the amount of fetal hemoglobin (HbF) produced. Sibling and twin studies indicate that some of that drug response variation is heritable. To test the hypothesis...

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Détails bibliographiques

Auteurs principaux:	Vivien A Sheehan, Jacy R Crosby, Aniko Sabo, Nicole A Mortier, Thad A Howard, Donna M Muzny, Shannon Dugan-Perez, Banu Aygun, Kerri A Nottage, Eric Boerwinkle, Richard A Gibbs, Russell E Ware, Jonathan M Flanagan
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2014-01-01
Collection:	PLoS ONE
Accès en ligne:	http://europepmc.org/articles/PMC4215999?pdf=render
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