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A novel mechanism of crosstalk between the p53 and NFκB pathways: MDM2 binds and inhibits p65RelA
The inflammation regulating transcription factor NFκB and the tumor-suppressing transcription factor p53 can act as functional antagonists. Chronic inflammation (NFκB activity) may contribute to the development of cancer through the inhibition of p53 function, while, conversely, p53 activity may dam...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Landes Bioscience
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3841326/ https://ncbi.nlm.nih.gov/pubmed/23839035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25495 |
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