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p53 mutations associated with aging-related rise in cancer incidence rates

TP53’s role as guardian of the genome diminishes with age, as the probability of mutation increases. Previous studies have shown an association between p53 gene mutations and cancer. However, the role of somatic TP53 mutations in the steep rise in cancer rates with aging has not been investigated at...

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Bibliographic Details
Main Author: Richardson, Richard B
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841325/
https://ncbi.nlm.nih.gov/pubmed/23839036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25494
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