Radioprotection of human lymphoid cells by exogenously supplied glutathione is mediated by gamma-glutamyl transpeptidase.
Human lymphoid cells depleted of glutathione by treatment with buthionine sulfoximine, a specific inhibitor of gamma-glutamylcysteine synthetase, may be partially repleted by adding glutathione in the medium. The mechanism of repletion involves the action of gamma-glutamyl transpeptidase on exogenou...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1983
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384114/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6136037/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.15.4714 |
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