CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.

Here we describe the properties of CP-154,526, a potent and selective nonpeptide antagonist of corticotropin (ACTH) releasing factor (CRF) receptors. CP-154,526 binds with high affinity to CRF receptors (Ki < 10 nM) and blocks CRF-stimulated adenylate cyclase activity in membranes prepared from rat...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Schulz, D W, Mansbach, R S, Sprouse, J, Braselton, J P, Collins, J, Corman, M, Dunaiskis, A, Faraci, S, Schmidt, A W, Seeger, T, Seymour, P, Tingley, F D, Winston, E N, Chen, Y L, Heym, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38410/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816826/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.19.10477
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