CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.

Here we describe the properties of CP-154,526, a potent and selective nonpeptide antagonist of corticotropin (ACTH) releasing factor (CRF) receptors. CP-154,526 binds with high affinity to CRF receptors (Ki < 10 nM) and blocks CRF-stimulated adenylate cyclase activity in membranes prepared from r...

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Dettagli Bibliografici
Autori principali: Schulz, D W, Mansbach, R S, Sprouse, J, Braselton, J P, Collins, J, Corman, M, Dunaiskis, A, Faraci, S, Schmidt, A W, Seeger, T, Seymour, P, Tingley, F D, Winston, E N, Chen, Y L, Heym, J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC38410/
https://ncbi.nlm.nih.gov/pubmed/8816826
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