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EFFECT OF DUAL INHIBITION OF APOPTOSIS AND AUTOPHAGY IN PROSTATE CANCER

PURPOSE: Targeting multiple anti-apoptotic proteins is now possible with the small molecule BH3 domain mimetics such as ABT-737. Given recent studies demonstrating that autophagy is a resistance mechanism to multiple therapeutic agents in the setting of apoptotic inhibition, we hypothesized that hyd...

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Detalhes bibliográficos
Main Authors: Saleem, Ahamed, Dvorzhinski, Dmitri, Santanam, Urmila, Mathew, Robin, Bray, Kevin, Stein, Mark, White, Eileen, DiPaola, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840901/
https://ncbi.nlm.nih.gov/pubmed/22241682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22487
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