The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin

BACKGROUND: There is growing evidence indicating the insulin-like growth factor 1 receptor (IGF-1R) plays a critical role in the progression of human colorectal carcinomas. IGF-1R is an attractive drug target for the treatment of colon cancer. Picropodophyllin (PPP), of the cyclolignan family, has r...

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Autores principales: Wang, Quan, Wei, Feng, Lv, Guoyue, Li, Chunsheng, Liu, Tongjun, Hadjipanayis, Costas G, Zhang, Guikai, Hao, Chunhai, Bellail, Anita C
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840673/
https://ncbi.nlm.nih.gov/pubmed/24182354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-521
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