CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

Atrophic age-related macular degeneration (AMD) is associated with the subretinal accumulation of mononuclear phagocytes (MPs). Their role in promoting or inhibiting retinal degeneration is unknown. We here show that atrophic AMD is associated with increased intraocular CCL2 levels and subretinal CC...

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Detalhes bibliográficos
Main Authors: Sennlaub, Florian, Auvynet, Constance, Calippe, Bertrand, Lavalette, Sophie, Poupel, Lucie, Hu, Shulong J, Dominguez, Elisa, Camelo, Serge, Levy, Olivier, Guyon, Elodie, Saederup, Noah, Charo, Israel F, Van Rooijen, Nico, Nandrot, Emeline, Bourges, Jean-Louis, Behar-Cohen, Francine, Sahel, José-Alain, Guillonneau, Xavier, Raoul, William, Combadiere, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840491/
https://ncbi.nlm.nih.gov/pubmed/24142887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201302692
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