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Detection of an altered DNA conformation at specific sites in chromatin and supercoiled DNA.
We show that bromoacetaldehyde, which reacts selectively at the N-1 and N-6 positions of unpaired adenine and at the N-3 and N-4 positions of unpaired cytosine residues reacts with chromosomal DNA in intact cells at probable regulatory sequences near active genes. A region of about 200 base pairs 5&...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1983
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384043/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6308620/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.14.4389 |
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