Fortilin reduces apoptosis in macrophages and promotes atherosclerosis

Atherosclerosis, a deadly disease insufficiently addressed by cholesterol-lowering drugs, needs new therapeutic strategies. Fortilin, a 172-amino acid multifunctional polypeptide, binds p53 and blocks its transcriptional activation of Bax, thereby exerting potent antiapoptotic activity. Although for...

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Main Authors: Pinkaew, Decha, Le, Rachel J., Chen, Yanjie, Eltorky, Mahmoud, Teng, Ba-Bie, Fujise, Ken
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2013
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840261/
https://ncbi.nlm.nih.gov/pubmed/24043250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00570.2013
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