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Fortilin reduces apoptosis in macrophages and promotes atherosclerosis
Atherosclerosis, a deadly disease insufficiently addressed by cholesterol-lowering drugs, needs new therapeutic strategies. Fortilin, a 172-amino acid multifunctional polypeptide, binds p53 and blocks its transcriptional activation of Bax, thereby exerting potent antiapoptotic activity. Although for...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3840261/ https://ncbi.nlm.nih.gov/pubmed/24043250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00570.2013 |
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