DB-02, a C-6-Cyclohexylmethyl Substituted Pyrimidinone HIV-1 Reverse Transcriptase Inhibitor with Nanomolar Activity, Displays an Improved Sensitivity against K103N or Y181C Than S-DABOs

6-(cyclohexylmethyl)-5-ethyl-2-((2-oxo-2-phenylethyl)thio)pyrimidin-4(3H)-one (DB-02) is a member of the newly reported synthetic anti-HIV-1 compounds dihydro-aryl/alkylsulfanyl-cyclohexylmethyl-oxopyrimidines, S-DACOs. In vitro anti-HIV-1 activity and resistance profile studies have suggested that...

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Main Authors: Zhang, Xing-Jie, Lu, Li-He, Wang, Rui-Rui, Wang, Yue-Ping, Luo, Rong-Hua, Cong Lai, Christopher, Yang, Liu-Meng, He, Yan-Ping, Zheng, Yong-Tang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839930/
https://ncbi.nlm.nih.gov/pubmed/24282600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081489
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